Article

Exosome-mediated LNA anti-miR delivery achieves potent miR-21 inhibition and PTEN restoration in podocytes

2026-07-17

Abstract excerpt

<h4>Background</h4> Podocyte injury and loss are central drivers of chronic kidney disease (CKD) progression and are involved in the majority of glomerular diseases. Among the molecular pathways implicated in podocyte dysfunction, microRNA-21 (miR-21) is consistently upregulated during glomerular injury and suppresses protective target genes including PTEN. Although anti-miR-21 approaches have shown high efficacy...

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Literature Corpus work: 6b0922c6-557f-55b7-8441-4ac38e9ec17a
DOI: 10.64898/2026.07.17.738885

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