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Article

DNA Hypermethylation of Myeloid Cells, A Novel Therapeutic Target in MDS and AML

27 Sept 2006

Abstract excerpt

Differential methylation of CpG islands is a regulatory mechanism for promoter activity of different classes of genes, including tissue-specific genes. These CpG islands are targets for transformation-associated, aberrant hypermethylation activity during leukemogenesis. Therefore the pharmacological reversion of this methylator phenotype (e.g. by reactivation of tumor suppressor gene expression) is an important...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 17076647
DOI: 10.2174/138920106778521523

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