Article

The pluripotency factor Tex10 finetunes Wnt signaling for PGC and male germline development

2023-02-24

Abstract excerpt

<h4>SUMMARY</h4> Testis-specific transcript 10 (Tex10) is a critical factor for pluripotent stem cell maintenance and preimplantation development. Here, we dissect its late developmental roles in primordial germ cell (PGC) specification and spermatogenesis using cellular and animal models. We discover that Tex10 binds the Wnt negative regulator genes, marked by H3K4me3, at the PGC-like cell (PGCLC) stage in restr...

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Identifiers and source

Literature Corpus work: ec8ac1bc-c905-5432-bf58-80b66aa8af8f
DOI: 10.1101/2023.02.23.529824

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