Article
A multi-omics approach reveals impaired lipid metabolism and oxidative stress in a zebrafish model of Alexander disease.
Redox biology - 1 Apr 2025
Bellitto Deianira, Bozzo Matteo, Ravera Silvia, Bertola Nadia, Rosamilia Francesca, Milia Jessica, Barboro Paola, Vargas Gabriela Coronel, Di Lisa Donatella, Pastorino Laura, Lantieri Francesca, Castagnola Patrizio, Iervasi Erika, Ponassi Marco, Profumo Aldo, Tkachenko Kateryna, Rosano Camillo, Candiani Simona, Bachetti Tiziana
Abstract excerpt
Alexander disease (AxD) is a rare leukodystrophy caused by heterozygous mutations in the GFAP gene. To date, several in vitro and in vivo models have been generated in an attempt to unravel the main mechanisms underlying this complex disease. However, none of these models is suitable for investigating the global dysregulation caused by AxD. To address this shortcoming, we have generated a stable transgenic...
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