Article

Widespread reorganisation of the regulatory chromatin landscape facilitates resistance to inhibition of oncogenic ERBB2 signalling

2021-04-29

Abstract excerpt

Oesophageal adenocarcinoma (OAC) patients show poor survival rates and there are few targeted molecular therapies available. However, components of the receptor tyrosine kinase (RTK) driven pathways are commonly mutated in OAC, typified by high frequency amplifications of the RTK ERRB2 . ERBB2 can be therapeutically targeted, but this has limited clinical benefit due to the acquisition of drug resistance. Here we...

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Literature Corpus work: ec81fa27-f9a8-5ca6-a0fd-0a5e14e3a377
DOI: 10.1101/2021.04.29.441944

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Widespread reorganisation of the regulatory chromatin landscape facilitates resistance to inhibition of oncogenic ERBB2 signallingDOI 10.1101/2021.04.29.441944Read

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