Article

Guided maturation of human neuromuscular organoids via electrical stimulation

2025-10-31

Abstract excerpt

Organoids derived from human pluripotent stem cells (hPSCs) are emerging as powerful models for studying development and disease. Despite their physiological relevance, the predictive power of organoids remains limited by the immature state of the constituent cells, posing a major challenge for mechanistic studies of adult physiology and late-onset diseases and disorders. Here, we establish a strategy for enhancin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ec7af678-d237-585b-80e4-551a56da0a92
DOI: 10.1101/2025.10.30.685366

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Guided maturation of human neuromuscular organoids via electrical stimulationDOI 10.1101/2025.10.30.685366Read

Electrical stimulation of biofidelic engineered muscle enhances myotube size, force, fatigue resistance, and induces a fast-to-slow-phenotype shift.Semantic proximity Read

Engineering human pluripotent stem cells into a functional skeletal muscle tissueSemantic proximity Read

Tissue-engineered neuromuscular organoidsSemantic proximity Read

Physical developmental cues for the maturation of human pluripotent stem cell-derived cardiomyocytesSemantic proximity Read

Long-Term Functional 3D Human Skeletal Muscle Constructs from Human Induced Pluripotent Stem Cells Enable Electrically Controlled Remodelling StudiesSemantic proximity Read

Stretched Exponential Modeling Reveals Drug-Specific Kinetics in Human Engineered Skeletal MuscleSemantic proximity Read

Bioengineered model of the human motor unit with physiologically functional neuromuscular junctionsSemantic proximity Read

Native extracellular matrix promotes human neuromuscular organoid morphogenesis and functionSemantic proximity Read

Simple and efficient differentiation of human iPSCs into contractible skeletal muscles for muscular disease modelingSemantic proximity Read

Dynamic Electrical Stimulation Promotes hiPSC-CM Differentiation and FunctionalitySemantic proximity Read

Generation of self-organized neuromusculoskeletal tri-tissue organoids from human pluripotent stem cellsSemantic proximity Read

3D in vitro models of skeletal muscle: myopshere, myobundle and bioprinted muscle constructSemantic proximity Read