Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Charge-altering releasable transporters enable phenotypic manipulation of natural killer cells for cancer immunotherapy.

Blood advances - 8 Sept 2020

Wilk Aaron J, Weidenbacher Nancy Lynn-Benner, Vergara Rosemary, Haabeth Ole A W, Levy Ronald, Waymouth Robert M, Wender Paul A, Blish Catherine A

Abstract excerpt

Chimeric antigen receptor (CAR) natural killer (NK) cells are an emerging cell therapy with promising results in oncology trials. However, primary human NK cells are difficult to transfect, hampering both mechanistic studies and clinical applications of NK cells. Currently, NK cell CAR modification relies on viral vectors or cell activation. The former raises cost and tolerability issues, while the latter alters...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to Immunotherapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Killer Cells, Natural

Share to Neoplasms

Share to Phenotype

Share to Receptors, Chimeric Antigen

Source

Open in PubMed Open full text

Identifiers

PMID: 32898247
DOI: 10.1182/bloodadvances.2020002355
PMCID: PMC7479957

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Charge-altering releasable transporters enable phenotypic manipulation of natural killer cells for cancer immunotherapy.PMID 32898247Read ↗

Charge-Altering Releasable Transporters Enable Specific Phenotypic Manipulation of Resting Primary Natural Killer CellsSemantic proximity Read ↗

Non-viral approaches in CAR-NK cell engineering: connecting natural killer cell biology and gene deliverySemantic proximity Read ↗

Gene-edited and CAR-NK cells: Opportunities and challenges with engineering of NK cells for immunotherapySemantic proximity Read ↗

Drug target validation in primary human natural killer cells using CRISPR RNPSemantic proximity Read ↗

A robust platform for expansion and genome editing of primary human natural killer cellsSemantic proximity Read ↗

CAR NK Cells: The Future Is NowSemantic proximity Read ↗

Nonviral technologies can pave the way for CAR-NK cell therapySemantic proximity Read ↗

Human CAR NK Cells: A New Non-viral Method Allowing High Efficient Transfection and Strong Tumor Cell KillingSemantic proximity Read ↗

Genetic Manipulation Approaches to Enhance the Clinical Application of NK Cell-Based ImmunotherapySemantic proximity Read ↗

NK cells specifically TCR-dressed to kill cancer cellsSemantic proximity Read ↗

Engineering NK Cells for CAR Therapy—Recent Advances in Gene Transfer MethodologySemantic proximity Read ↗

Nonviral genome engineering of natural killer cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.