Article

Tau-related reduction of glucose metabolism in mild cognitive impairment occurs independently of APOE ε4 genotype and is gradually modulated by β-amyloid

2024-01-23

Abstract excerpt

<h4>Background</h4> PET imaging studies have shown that spatially distributed measurements of β-amyloid are significantly correlated with glucose metabolism in Mild Cognitive Impairment (MCI) independently of the APOE ε4 genotype. In contrast, the relationship between tau and glucose metabolism at different stages of Alzheimer’s Disease (AD) has not been fully understood. <h4>Objective</h4> We hypothesize that s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ec1a99e0-d552-585e-ad57-c58f09a7981b
DOI: 10.1101/2024.01.23.576866

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tau-related reduction of glucose metabolism in mild cognitive impairment occurs independently of APOE ε4 genotype and is gradually modulated by β-amyloidDOI 10.1101/2024.01.23.576866Read

Spatially Distributed Amyloid-β Reduces Glucose Metabolism in Mild Cognitive Impairment.Semantic proximity Read

Patterns of Glucose Metabolism in [<sup>18</sup>F]FDG PET Indicate Regional Variability and Neurodegeneration in the Progression of Alzheimer’s DementiaSemantic proximity Read

<i>APOE4</i>and Infectious Diseases Jointly Contribute to Brain Glucose Hypometabolism, a Biomarker of Alzheimer’s Pathology: New Findings from the ADNISemantic proximity Read

Topographical APOE ɛ4 Genotype Influence on Cerebral Metabolism in the Continuum of Alzheimer's Disease: Amyloid Burden Adjusted Analysis.Semantic proximity Read

Elevated blood glucose levels are associated with the progression of brain hypometabolism, and HDL-C and<i>APOE4</i>add to this associationSemantic proximity Read

Gray matter microstructure from in-vivo diffusion MRI reflects post-mortem neuropathology severity and clinical progression of Alzheimer’s diseaseSemantic proximity Read

Effect of APOE ε4 genotype on amyloid-β and tau accumulation in Alzheimer’s diseaseSemantic proximity Read

The impact of APOE ε4 in Alzheimer’s disease: a meta-analysis of voxel-based morphometry studiesSemantic proximity Read

Multiple Effect of APOE Genotype on Clinical and Neuroimaging Biomarkers Across Alzheimer's Disease Spectrum.Semantic proximity Read

APOE ε4–associated heterogeneity of neuroimaging biomarkers across the Alzheimer's disease continuumSemantic proximity Read

Glucose Dysregulation Interacts With APOE-∊4 to Potentiate Temporoparietal Cortical Thinning.Semantic proximity Read