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Article

Spatially Distributed Amyloid-β Reduces Glucose Metabolism in Mild Cognitive Impairment.

Journal of Alzheimer's disease : JAD - 1 Jan 2020

Carbonell Felix, Zijdenbos Alex P, Bedell Barry J

Abstract excerpt

BACKGROUND: Several positron emission tomography (PET) studies have explored the relationship between amyloid-β (Aβ), glucose metabolism, and the APOEɛ4 genotype. It has been reported that APOEɛ4, and not aggregated Aβ, contributes to glucose hypometabolism in pre-clinical stages of Alzheimer's disease (AD) pathology. OBJECTIVE: We hypothesize that typical measurements of Aβ taken either from composite...

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Source

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Identifiers

PMID: 31796668
DOI: 10.3233/JAD-190560
PMCID: PMC7029335

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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