Article

Constitutive expression of IκBζ promotes tumor growth and immunotherapy resistance in melanoma

2024-09-24

Abstract excerpt

<h4>Background</h4> IκBζ, a rather unknown co-regulator of NF-κB, is mostly inducibly expressed and can either activate or repress a specific subset of NF-κB target genes. While its role as a transcriptional regulator of various cytokines and chemokines in immune cells has been revealed, IκBζ’s function in solid cancer remains unclear. <h4>Methods</h4> We investigated IκBζ expression in melanoma, and assessed it...

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Literature Corpus work: ec0dbc58-80f8-52e9-9c0b-aa9d4ff532ba
DOI: 10.1101/2024.09.19.613946

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