Article

B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma

2018-11-26

Abstract excerpt

Tumor associated inflammation predicts response to immune checkpoint blockade in human melanoma. Established mechanisms that underlie therapy response and resistance center on anti-tumor T cell responses. Here we show that tumor-associated B cells are vital to tumor associated inflammation. Autologous B cells were directly induced by melanoma conditioned medium, expressed pro- and anti-inflammatory factors, and di...

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Identifiers and source

Literature Corpus work: e43003a9-9051-59ad-8dc9-04f7c1151bfd
DOI: 10.1101/478735

Open publication

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