Article
BAP1 mutations inhibit the NF-κB signaling pathway to induce an immunosuppressive microenvironment in uveal melanoma.
Molecular medicine (Cambridge, Mass.) - 14 Sept 2023
Zhang Chao, Wu Shuai
Abstract excerpt
BACKGROUND: Tumor immune microenvironment regulates the growth and metastasis of uveal melanoma (UM). This study aims to reveal the possible molecular mechanism of BRCA1-associated protein 1 (BAP1) mutations in affecting the tumor immune microenvironment in UM through mediating the nuclear factor-κB (NF-κB) signaling pathway. METHODS: TCGA and cBioPortal databases jointly analyzed the genes with high mutation...
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