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Global Threat of Metallo-β-Lactamase-Producing Multidrug-Resistant Bacteria: Molecular Insights, Risk Factors, and Urgent Challenges

2026-06-04

Abstract excerpt

Metallo-β-lactamase (MBL)-producing multidrug-resistant (MDR) bacteria have emerged as one of the most critical threats to global public health. These zinc-dependent enzymes, particularly NDM, VIM, and IMP, hydrolyze carbapenems, the last-resort antibiotics for treating severe Gram-negative infections. Unlike serine-β-lactamases, MBLs evade all clinically approved β-lactamase inhibitors, leaving a profound therape...

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Literature Corpus work
7ffe140b-e48c-51d0-86e2-9cd908c11697
DOI
10.20944/preprints202606.0401.v1
Open publication

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