Article
Drug voyager: a computational platform for exploring unintended drug action.
BMC bioinformatics - 28 Feb 2017
Oh Min, Ahn Jaegyoon, Lee Taekeon, Jang Giup, Park Chihyun, Yoon Youngmi
Abstract excerpt
BACKGROUND: The dominant paradigm in understanding drug action focuses on the intended therapeutic effects and frequent adverse reactions. However, this approach may limit opportunities to grasp unintended drug actions, which can open up channels to repurpose existing drugs and identify rare adverse drug reactions. Advances in systems biology can be exploited to comprehensively understand pharmacodynamic actions,...
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