Article

XL-Ranker: A Computational Workflow for Prioritizing Protein-Protein Interactions from Cross-Linking Mass Spectrometry Data

2025-07-23

Abstract excerpt

Protein-protein interactions (PPIs) are central to virtually all biological processes, and their disruption can lead to a wide spectrum of human diseases. Cross-linking mass spectrometry (XL-MS) enables proteome-scale detection of interacting peptide pairs, from which PPIs can be inferred. However, interpretating XL-MS data to assign homologous cross-linked peptide pairs to specific protein interactions can be cha...

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Literature Corpus work: ebd0ac3b-4100-5ee5-8e53-d072faaf5f0e
DOI: 10.1101/2025.07.18.665625

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