Article
Functional analysis beyond enrichment: non-redundant reciprocal linkage of genes and biological terms.
PloS one - 1 Jan 2011
Fontanillo Celia, Nogales-Cadenas Ruben, Pascual-Montano Alberto, De las Rivas Javier
Abstract excerpt
Functional analysis of large sets of genes and proteins is becoming more and more necessary with the increase of experimental biomolecular data at omic-scale. Enrichment analysis is by far the most popular available methodology to derive functional implications of sets of cooperating genes. The problem with these techniques relies in the redundancy of resulting information, that in most cases generate lots of...
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