Article
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha.
Cell - 15 Dec 2006
Lagouge Marie, Argmann Carmen, Gerhart-Hines Zachary, Meziane Hamid, Lerin Carles, Daussin Frederic, Messadeq Nadia, Milne Jill, Lambert Philip, Elliott Peter, Geny Bernard, Laakso Markku, Puigserver Pere, Auwerx Johan
Abstract excerpt
Diminished mitochondrial oxidative phosphorylation and aerobic capacity are associated with reduced longevity. We tested whether resveratrol (RSV), which is known to extend lifespan, impacts mitochondrial function and metabolic homeostasis. Treatment of mice with RSV significantly increased their aerobic capacity, as evidenced by their increased running time and consumption of oxygen in muscle fibers. RSV's...
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