Article

Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies

2020-12-15

Abstract excerpt

<h4>ABSTRACT</h4> Antibodies against coronavirus spike protein potently protect against infection and disease, however it remains unclear if such protection can be extended to variant coronaviruses. This is exemplified by a set of iconic and well-characterized monoclonal antibodies developed after the 2003 SARS outbreak including mAbs m396, CR3022, CR3014 and 80R, which potently neutralize SARS-CoV-1, but not SAR...

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Literature Corpus work: eb5d37a8-daaa-52f0-bf7f-e3677e29c85c
DOI: 10.1101/2020.12.14.422791

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