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Article

The Regulation of Steroid Action by Sulfation and Desulfation.

Endocrine reviews - 1 Oct 2015

Mueller Jonathan W, Gilligan Lorna C, Idkowiak Jan, Arlt Wiebke, Foster Paul A

Abstract excerpt

Steroid sulfation and desulfation are fundamental pathways vital for a functional vertebrate endocrine system. After biosynthesis, hydrophobic steroids are sulfated to expedite circulatory transit. Target cells express transmembrane organic anion-transporting polypeptides that facilitate cellular uptake of sulfated steroids. Once intracellular, sulfatases hydrolyze these steroid sulfate esters to their...

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Identifiers

PMID: 26213785
DOI: 10.1210/er.2015-1036
PMCID: PMC4591525

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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