Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of the adult ADHD-associated gene ADGRL3 is dysregulated by risk variants and environmental risk factors.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Jun 2021

McNeill Rhiannon V, Palladino Viola Stella, Brunkhorst-Kanaan Nathalie, Grimm Oliver, Reif Andreas, Kittel-Schneider Sarah

Abstract excerpt

OBJECTIVES: ADGRL3 is a well-replicated risk gene for adult ADHD, encoding the G protein-coupled receptor latrophilin-3 (LPHN3). However, LPHN3's potential role in pathogenesis is unclear. We aimed to determine whether ADGRL3 expression could be dysregulated by genetic risk variants and/or ADHD-associated environmental risk factors. METHODS: Eighteen adult ADHD patients and healthy controls were genotyped for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Attention Deficit Disorder with Hyperactivity
Share to Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Receptors, G-Protein-Coupled

Share to Receptors, Peptide

Share to Risk Factors

Source

Identifiers

PMID: 32787626
DOI: 10.1080/15622975.2020.1809014

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of the adult ADHD-associated gene ADGRL3 is dysregulated by risk variants and environmental risk factors.PMID 32787626Read ↗

Expression profile of the ADHD risk gene <i>ADGRL3</i> during human neurodevelopment and the effects of genetic variationSemantic proximity Read ↗

Meta-analysis and systematic review of ADGRL3 (LPHN3) polymorphisms in ADHD susceptibility.Semantic proximity Read ↗

ADGRL3 rs6551665 as a Common Vulnerability Factor Underlying Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder.Semantic proximity Read ↗

Contribution of LPHN3 to the genetic susceptibility to ADHD in adulthood: a replication study.Semantic proximity Read ↗

ADGRL3 genomic variation implicated in neurogenesis and ADHD links functional effects to the incretin polypeptide GIPSemantic proximity Read ↗

<i> <scp>ADGRL</scp> 3 ( <scp>LPHN</scp> 3) </i> variants are associated with a refined phenotype of <scp>ADHD</scp> in the <scp>MTA</scp> studySemantic proximity Read ↗

Dances with black widow spiders: dysregulation of glutamate signalling enters centre stage in ADHD.Semantic proximity Read ↗

An Ultraconserved Brain-Specific Enhancer Within ADGRL3 (LPHN3) Underpins Attention-Deficit/Hyperactivity Disorder Susceptibility.Semantic proximity Read ↗

LPHN3 and attention-deficit/hyperactivity disorder: interaction with maternal stress during pregnancy.Semantic proximity Read ↗

A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication.Semantic proximity Read ↗

Genetic Variation Underpinning ADHD Risk in a Caribbean CommunitySemantic proximity Read ↗

Generation of four human induced pluripotent stem cells derived from ADHD patients carrying different genotypes for the risk SNP rs1397547 in the ADHD-associated gene ADGRL3.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.