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Article

An Ultraconserved Brain-Specific Enhancer Within ADGRL3 (LPHN3) Underpins Attention-Deficit/Hyperactivity Disorder Susceptibility.

Biological psychiatry - 15 Dec 2016

Martinez Ariel F, Abe Yu, Hong Sungkook, Molyneux Kevin, Yarnell David, Löhr Heiko, Driever Wolfgang, Acosta Maria T, Arcos-Burgos Mauricio, Muenke Maximilian

Abstract excerpt

BACKGROUND: Genetic factors predispose individuals to attention-deficit/hyperactivity disorder (ADHD). Previous studies have reported linkage and association to ADHD of gene variants within ADGRL3. In this study, we functionally analyzed noncoding variants in this gene as likely pathological contributors. METHODS: In silico, in vitro, and in vivo approaches were used to identify and characterize evolutionary...

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Identifiers

PMID: 27692237
DOI: 10.1016/j.biopsych.2016.06.026
PMCID: PMC5108697

Genes

ADGRL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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