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Article

Rare genetic variants confer a high risk of ADHD and implicate neuronal biology.

Nature - 1 Jan 2026

Demontis Ditte, Duan Jinjie, Hsu Yu-Han H, Pintacuda Greta, Grove Jakob, Nielsen Trine Tollerup, Thirstrup Janne, Martorana Makayla, Botts Travis, Satterstrom F Kyle, Bybjerg-Grauholm Jonas, Tsai Jason H Y, Glerup Simon, Hoogman Martine, Buitelaar Jan, Klein Marieke, Ziegler Georg C, Jacob Christian, Grimm Oliver, Bayas Maximilian, Kobayashi Nene F, Kittel-Schneider Sarah, Lesch Klaus-Peter, Franke Barbara, Reif Andreas, Agerbo Esben, Werge Thomas, Nordentoft Merete, Mors Ole, Mortensen Preben Bo, Lage Kasper, Daly Mark J, Neale Benjamin M, Børglum Anders D

Abstract excerpt

Attention deficit hyperactivity disorder (ADHD) is a childhood-onset neurodevelopmental disorder with a large genetic component1. It affects around 5% of children and 2.5% of adults2, and is associated with several severe outcomes3-11. Common genetic variants associated with the disorder have been identified12,13, but the role of rare variants in ADHD is mostly unknown. Here, by analysing rare coding variants in...

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Identifiers

PMID: 41224997
DOI: 10.1038/s41586-025-09702-8
PMCID: PMC12823435

Genes

ANK2
ANO8
MAP1A

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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