Article

Plasma Proteomics Identifies LEP and FABP4 as Key Mediators of Obesity-Related Knee Osteoarthritis

2026-08-01

Abstract excerpt

Objectives To identify and validate molecular markers for obesity-related knee osteoarthritis (OB + OA + ) by integrating proteomic and genetic data. Methods Plasma samples from 171 primary knee OA patients, including 86 OB+OA+ and 85 OB-OA+ patients, with age, sex, and comorbidities matched between the 2 groups, were analyzed using the Olink Explore HT platform, quantifying 5,416 proteins. Logistic regression mod...

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Literature Corpus work: eaaafe80-5783-57a4-890c-4ef693264cca
DOI: 10.3899/jrheum.2026-0447.166

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