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Article

Uncovering causal genetic mediators linking redefined obesity to osteoarthritis: Multidimensional analysis from population to genetic mechanisms.

Osteoarthritis and cartilage - 1 Feb 2026

Yang Tengyun, Jia Chao, Wang Guoliang, Zhang Wen, Zhu Boheng, Li Xia, Chen Leijie, Li Yanlin, Teng Zhaowei

Abstract excerpt

OBJECTIVE: To examine the causal association between obesity and osteoarthritis (OA) using an improved definition of obesity, and to identify mediating genes that may link obesity to OA pathogenesis. DESIGN: We analyzed data from the U.S. National Health and Nutrition Examination Survey (NHANES, 2011-2018; n = 8981). Obesity was defined using body mass index (BMI ≥ 30 kg/m²) combined with body fat percentage (BFP...

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Identifiers

PMID: 41218721
DOI: 10.1016/j.joca.2025.11.003

Genes

MAPK3
RBM6
PRMT6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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