Chromatin accessibility analysis uncovers regulatory element landscape in prostate cancer progression

Abstract excerpt

Aberrant oncogene functions and structural variation alter the chromatin structure in cancer cells. While gene regulation by chromatin states has been studied extensively, chromatin accessibility and its relevance in aberrant gene expression during prostate cancer progression is not well understood. Here, we report a genome-wide chromatin accessibility analysis of clinical tissue samples of benign prostatic hyperp...

Topics

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• Binding Sites
• CCCTC-Binding Factor
• Epigenetics and DNA Methylation
• Gene Expression Regulation, Neoplastic
• Gene Regulatory Networks
• Prostate Cancer Treatment and Research
• Prostatic Neoplasms
• Protein Binding

Identifiers and source

Literature Corpus work

ea9de366-bd43-575f-a834-83d9efdb775b

DOI

10.1101/2020.09.08.287268