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Endosomal Localization of the Serum Resistance-Associated Protein in African Trypanosomes Confers Human Infectivity

25 Jun 2011

Abstract excerpt

Trypanosoma brucei rhodesiense is the causative agent of human African sleeping sickness. While the closely related subspecies T. brucei brucei is highly susceptible to lysis by a subclass of human high-density lipoproteins (HDL) called trypanosome lytic factor (TLF), T. brucei rhodesiense is resistant and therefore able to establish acute and fatal infections in humans. This resistance is due to expression of...

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PMID: 21705681
DOI: 10.1128/ec.05112-11

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