Article

Transcriptomic Signature-Guided Depletion of Intermediate Alveolar Epithelial Cells Ameliorates Pulmonary Fibrosis in Mice

2025-05-21

Abstract excerpt

<title>Abstract</title> <p> Single-cell RNA sequencing (scRNA-seq) analyses of human and murine models of pulmonary fibrosis have uncovered multiple novel cell states involved in lung repair and regeneration, including an intermediate epithelial cell state identified as the KRT5-/KRT17+ aberrant basaloid cells in humans and the cytokeratin 8-positive alveolar differentiation intermediate (Krt8+ ADI) in mice. How...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ea85f9a7-a1c9-5820-bb1f-7acad35ab2d1
DOI: 10.21203/rs.3.rs-6623390/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptomic Signature-Guided Depletion of Intermediate Alveolar Epithelial Cells Ameliorates Pulmonary Fibrosis in MiceDOI 10.21203/rs.3.rs-6623390/v1Read

Longitudinal single cell transcriptomics reveals Krt8+ alveolar epithelial progenitors in lung regenerationSemantic proximity Read

Cross-species integration of single-cell RNA-seq resolved alveolar-epithelial transitional states in idiopathic pulmonary fibrosisSemantic proximity Read

scRNA-Seq-based drug repurposing targeting idiopathic pulmonary fibrosis (IPF)Semantic proximity Read

Single-cell RNA-sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosisSemantic proximity Read

Single-cell RNA sequencing reveals novel cell differentiation dynamics during human airway epithelium regenerationSemantic proximity Read

Characterization of a flexible AAV-DTR/DT mouse model of acute epithelial lung injurySemantic proximity Read

Cell division tracing combined with single-cell transcriptomics reveals new cell types and differentiation paths in the regenerating mouse lungSemantic proximity Read

Abnormal respiratory progenitors in fibrotic lung injurySemantic proximity Read

IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosisSemantic proximity Read

Single-cell division tracing and transcriptomics reveal cell types and differentiation paths in the regenerating lungSemantic proximity Read

Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosisSemantic proximity Read

Single cell RNA Sequencing Identifies G-protein Coupled Receptor 87 as a Novel Basal Cell Marker of Distal Honeycomb Cysts in Idiopathic Pulmonary FibrosisSemantic proximity Read