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Extracellular Vesicle‐Contained Thrombospondin 1 Retards Age‐Related Degenerative Tendinopathy by Rejuvenating Tendon Stem/Progenitor Cell Senescence

22 May 2024

Abstract excerpt

Advanced age is a major risk factor for age-related degenerative tendinopathy. During aging, tendon stem/progenitor cell (TSPC) function declines owing to the transition from a normal quiescent state to a senescent state. Extracellular vesicles (EVs) from young stem cells are reported to possess anti-aging functions. However, it remains unclear whether EVs from young TSPCs (TSPC-EVs) can rejuvenate senescent...

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PMID: 38778750
DOI: 10.1002/smll.202400598

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