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The Histone H2B Arg95 residue links the Pheromone Response Pathway to Rapamycin-Induced G1 Arrest in Yeast

2022-03-15

Abstract excerpt

Rapamycin is an immunosuppressant used for treating many types of diseases such as kidney carcinomas. In yeast, rapamycin inhibits the TORC1 kinase signaling pathway causing rapid alteration in gene expression and ultimately cell cycle arrest in G 1 through mechanisms that are not fully understood. Herein, we screened a histone mutant collection and report that one of the mutants, H2B R95A, is strikingly resistant...

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Literature Corpus work
ea1f2fad-d788-571f-ba40-142e25995f34
DOI
10.21203/rs.3.rs-1439695/v1
Open publication

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The Histone H2B Arg95 residue links the Pheromone Response Pathway to Rapamycin-Induced G1 Arrest in YeastDOI 10.21203/rs.3.rs-1439695/v1
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