Article
The structural basis of pathogenic subgenomic flavivirus RNA (sfRNA) production.
Science (New York, N.Y.) - 18 Apr 2014
Chapman Erich G, Costantino David A, Rabe Jennifer L, Moon Stephanie L, Wilusz Jeffrey, Nix Jay C, Kieft Jeffrey S
Abstract excerpt
Flaviviruses are emerging human pathogens and worldwide health threats. During infection, pathogenic subgenomic flaviviral RNAs (sfRNAs) are produced by resisting degradation by the 5'→3' host cell exonuclease Xrn1 through an unknown RNA structure-based mechanism. Here, we present the crystal structure of a complete Xrn1-resistant flaviviral RNA, which contains interwoven pseudoknots within a compact structure...
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