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Article

Modeling spinal muscular atrophy in <i>Drosophila</i> links <i>Smn</i> to FGF signaling

7 Feb 2011

Abstract excerpt

Spinal muscular atrophy (SMA), a devastating neurodegenerative disorder characterized by motor neuron loss and muscle atrophy, has been linked to mutations in the Survival Motor Neuron (SMN) gene. Based on an SMA model we developed in Drosophila, which displays features that are analogous to the human pathology and vertebrate SMA models, we functionally linked the fibroblast growth factor (FGF) signaling pathway...

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PMID: 21300852
DOI: 10.1083/jcb.201004016

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