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Article

Immune dysregulation may contribute to disease pathogenesis in spinal muscular atrophy mice

21 Dec 2016

Abstract excerpt

Spinal muscular atrophy (SMA) has long been solely considered a neurodegenerative disorder. However, recent work has highlighted defects in many other cell types that could contribute to disease aetiology. Interestingly, the immune system has never been extensively studied in SMA. Defects in lymphoid organs could exacerbate disease progression by neuroinflammation or immunodeficiency. Smn depletion led to severe...

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PMID: 28108555
DOI: 10.1093/hmg/ddw434

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