Article
A rationally designed mimotope library for profiling of the human IgM repertoire
2018-04-26
Abstract excerpt
Specific antibody reactivities are routinely used as biomarkers but the use of antibody repertoire profiles is still awaiting recognition. Here we suggest to expedite the adoption of this class of system level biomarkers by rationally designing a peptide array as an efficient probe for an appropriately chosen repertoire compartment. Most IgM antibodies are characterized by few somatic mutations, polyspecificity an...
Topics
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- Advanced Biosensing Techniques and Applications
- Glycosylation and Glycoproteins Research
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Protein purification and stability
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- vaccines and immunoinformatics approaches
Identifiers and source
- Literature Corpus work
- e9f38211-2897-5e69-bb47-683d8a9fc17b
- DOI
- 10.1101/308973