From Ions to Chaos: exploring a whole-brain modelling framework in the mouse

Abstract excerpt

Computational neuroscience offers powerful tools for understanding brain function in both healthy and diseased states. However, detailed data on microscale mechanisms—such as those involved in genetics and pharmacology—are often derived from mouse experiments and further lack integration into whole-brain models. In this work, we bridge microscale ion-channel dynamics and macroscale network behavior by employing th...

Topics

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• Action Potentials
• Arrhythmias, Cardiac
• Data Interpretation, Statistical
• Databases, Factual
• Hippocampus
• Models, Neurological
• Neurons
• Phenotype

Identifiers and source

Literature Corpus work

e9d9e375-2000-5d77-bc9e-64f4041cc8d5

DOI

10.64898/2025.12.04.691835