Article

Tissue Reassembly with Generative AI

2025-02-17

Abstract excerpt

The spatial arrangement of cells is fundamental to their function, but single-cell RNA sequencing loses spatial context by dissociating cells from tissues. We present LUNA, a generative AI model that reassembles dissociated cells into tissue structures solely from gene expression by learning spatial priors from existing spatially resolved datasets. We apply and validate LUNA across multiple technologies including...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e9d869b7-596e-5ea0-bb83-59137991afc6
DOI: 10.1101/2025.02.13.638045

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Tissue Reassembly with Generative AIDOI 10.1101/2025.02.13.638045Read

MIMYR: Generative modeling of missing tissue in spatial transcriptomicsSemantic proximity Read

Nicheformer: a foundation model for single-cell and spatial omicsSemantic proximity Read

Construction of a 3D whole organism spatial atlas by joint modeling of multiple slicesSemantic proximity Read

Query-driven generative AI synthesizes multi-modal spatial omics from histologySemantic proximity Read

Comprehensive mapping of tissue cell architecture via integrated single cell and spatial transcriptomicsSemantic proximity Read

A Cross-Species Generative Cell Atlas Across 1.5 Billion Years of Evolution: The TranscriptFormer Single-cell ModelSemantic proximity Read

CellDiffusion: a generative model to annotate single-cell and spatial RNA-seq using bulk referencesSemantic proximity Read

Enhancing Pan-cancer Spatial Transcriptomics at Single-cell Resolution with STPAINTERSemantic proximity Read

Inference of single cell profiles from histology stains with the Single Cell omics from Histology Analysis Framework (SCHAF)Semantic proximity Read

Joint cell type identification in spatial transcriptomics and single-cell RNA sequencing dataSemantic proximity Read

Deep generative model embedding of single-cell RNA-Seq profiles on hyperspheres and hyperbolic spacesSemantic proximity Read

Construction of continuously expandable single-cell atlases through integration of heterogeneous datasets in a generalized cell-embedding spaceSemantic proximity Read