Article

CellDiffusion: a generative model to annotate single-cell and spatial RNA-seq using bulk references

2025-10-28

Abstract excerpt

Annotating single-cell and spatial RNA-seq data can be greatly enhanced by leveraging bulk RNA-seq, which remains a cost-effective and well-established benchmark for characterising transcriptional activity in immune cell populations. However, a major technical hurdle lies in the contrasting properties of these data types: single-cell and spatial data are inherently sparse due to its cell-level sampling scheme, lea...

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Literature Corpus work: 6a19de0e-4784-5850-be3b-2c77c7ddbabd
DOI: 10.1101/2025.10.27.684671

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