Article

A Cross-Species Generative Cell Atlas Across 1.5 Billion Years of Evolution: The TranscriptFormer Single-cell Model

2025-04-29

Abstract excerpt

Single-cell transcriptomics has revolutionized our understanding of cellular diversity, yet our understanding of the transcriptional programs across the tree of life remains limited. Here we present TranscriptFormer, a family of generative foundation models trained on up to 112 million cells spanning 1.53 billion years of evolution across 12 species. By jointly modeling gene identities and expression levels using...

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Literature Corpus work: 46d7f957-3118-5e2a-a121-accc3d5173ed
DOI: 10.1101/2025.04.25.650731

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