Article

Construction of continuously expandable single-cell atlases through integration of heterogeneous datasets in a generalized cell-embedding space

2021-04-28

Abstract excerpt

<title>Abstract</title> <p>Single-cell RNA-seq and ATAC-seq analyses have been widely applied to decipher cell-type and regulation complexities. However, experimental conditions often confound biological variations when comparing data from different samples. For integrative single-cell data analysis, we have developed SCALEX, a deep generative framework that maps cells into a generalized, batch-invariant cell-emb...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 44dc9e1a-ea8f-5d9d-8179-833651c10b1b
DOI: 10.21203/rs.3.rs-398163/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Construction of continuously expandable single-cell atlases through integration of heterogeneous datasets in a generalized cell-embedding spaceDOI 10.21203/rs.3.rs-398163/v1Read

Online single-cell data integration through projecting heterogeneous datasets into a common cell-embedding spaceSemantic proximity Read

Population-level integration of single-cell datasets enables multi-scale analysis across samplesSemantic proximity Read

Universal Cell Embeddings: A Foundation Model for Cell BiologySemantic proximity Read

inVAE: Conditionally invariant representation learning for generating multivariate single-cell reference mapsSemantic proximity Read

scDREAMER: atlas-level integration of single-cell datasets using deep generative model paired with adversarial classifierSemantic proximity Read

Automatic cell type harmonization and integration across Human Cell Atlas datasetsSemantic proximity Read

Sfaira accelerates data and model reuse in single cell genomicsSemantic proximity Read

Enhancement of Network Architecture Alignment in Comparative Single-Cell StudiesSemantic proximity Read

CellDiffusion: a generative model to annotate single-cell and spatial RNA-seq using bulk referencesSemantic proximity Read

UniCell: Towards a Unified Solution for Cell Annotation, Nomenclature Harmonization, Atlas Construction in Single-Cell TranscriptomicsSemantic proximity Read

Enhancement of network architecture alignment in comparative single-cell studiesSemantic proximity Read