Scalable Condition-relevant Cell Niche Analysis of Spatial Omics Data with Taichi

Abstract excerpt

Tissues are composed of heterogeneous cell niches, which can be investigated using spatial omics technologies. Large consortia have accumulated vast amounts of spatially resolved data, which typically assign slice-level condition labels without considering intra-slice heterogeneity, particularly differential cell niches that respond to certain perturbations. Here, we present Taichi, an efficient and scalable metho...

Topics

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• Algorithms
• Biomarkers, Tumor
• Cluster Analysis
• Gene Expression Regulation, Neoplastic
• Microscopy
• Neoplasms
• Neural Networks, Computer
• Phenotype

Identifiers and source

Literature Corpus work

c58bee02-e07e-5fd1-9aaf-32db14988dbe

DOI

10.1101/2024.05.30.596656