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A Tale of Two Moieties: Rapidly Evolving CRISPR/Cas-Based Genome Editing.

Trends in biochemical sciences - 1 Oct 2020

Yang Li, Chen Jia

Abstract excerpt

Two major moieties in genome editing are required for precise genetic changes: the locator moiety for target binding and the effector moiety for genetic engineering. By taking advantage of CRISPR/Cas, which consists of different modules for independent target binding and cleavage, a spectrum of precise and versatile genome editing technologies have been developed for broad applications in biomedical research,...

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PMID: 32616331
DOI: 10.1016/j.tibs.2020.06.003

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