Multiomic Characterization of Meningiomas Informs Cell of Origin and Identifies Immune Dysregulation at the Blood-CSF Barrier

Abstract excerpt

<title>Abstract</title> <p> Meningiomas represent 1/3 of adult brain tumors and arise from the meninges, a layered immune organ that forms the blood CSF-barrier. While molecular characterization has revolutionized our capacity to distinguish benign from aggressive tumors, the developmental relationship between meningiomas and the specialized layers of the meninges remains underexplored. Using single cell transcr...

Topics

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• Data Analysis
• DNA Methylation
• Drug Discovery
• Glioma Diagnosis and Treatment
• Head and Neck Surgical Oncology
• Meningioma
• Meningioma and schwannoma management
• Proteogenomics

Identifiers and source

Literature Corpus work

42a20be3-0fd6-5fbd-9de8-6cc4ab8cf760

DOI

10.21203/rs.3.rs-8612817/v1