Functional characterization of the dural sinuses as a neuroimmune interface.

doi:10.1016/j.cell.2020.12.040

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Article

Functional characterization of the dural sinuses as a neuroimmune interface.

Cell - 18 Feb 2021

Rustenhoven Justin, Drieu Antoine, Mamuladze Tornike, de Lima Kalil Alves, Dykstra Taitea, Wall Morgan, Papadopoulos Zachary, Kanamori Mitsuhiro, Salvador Andrea Francesca, Baker Wendy, Lemieux Mackenzie, Da Mesquita Sandro, Cugurra Andrea, Fitzpatrick James, Sviben Sanja, Kossina Ross, Bayguinov Peter, Townsend Reid R, Zhang Qiang, Erdmann-Gilmore Petra, Smirnov Igor, Lopes Maria-Beatriz, Herz Jasmin, Kipnis Jonathan

Abstract excerpt

Despite the established dogma of central nervous system (CNS) immune privilege, neuroimmune interactions play an active role in diverse neurological disorders. However, the precise mechanisms underlying CNS immune surveillance remain elusive; particularly, the anatomical sites where peripheral adaptive immunity can sample CNS-derived antigens and the cellular and molecular mediators orchestrating this...

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PMID: 33508229
DOI: 10.1016/j.cell.2020.12.040
PMCID: PMC8487654

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