Article

Lonafarnib Partially Reverses Cardiac Senescence in Human and Mouse Progeria Models via Autophagy Activation

2025-07-02

Abstract excerpt

<h4>ABSTRACT</h4> Hutchinson-Gilford Progeria Syndrome (HGPS), characterised by accelerated ageing, causes cardiovascular defects resembling aspects of cardiovascular ageing. We used human left ventricle cardiomyocytes (CMs) derived from HGPS-induced pluripotent stem cells (iPSCs), and their isogenic-corrected controls, to investigate HGPS-CM dysfunction and identify potential therapies. Our results revealed that...

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Literature Corpus work: e9579549-bbe1-5f02-bf07-9d0ca12fd0bb
DOI: 10.1101/2025.06.27.661680

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