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Article

Cardiomyocyte Contractility and Autophagy in a Premature Senescence Model of Cardiac Aging

15 Apr 2020

Abstract excerpt

Globally, cardiovascular diseases are the leading cause of death in the aging population. While the clinical pathology of the aging heart is thoroughly characterized, underlying molecular mechanisms are still insufficiently clarified. The aim of the present study was to establish an in vitro model system of cardiomyocyte premature senescence, culturing heart muscle cells derived from neonatal C57Bl/6J mice for 21...

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PMID: 32377307
DOI: 10.1155/2020/8141307

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