Article

Significance of KDM6A Mutation in Bladder Cancer Immune Escape

2020-12-17

Abstract excerpt

<h4>Background: </h4> Bladder cancer (BC)is the fourth most prevalent neoplasm in menand is associated with high tumour recurrence rates, leading to major treatment challenges. Lysine-specific demethylase 6A ( KDM6A ) is frequently mutated in several cancer types; however, its effects on tumour progression and clinical outcome in BCremain unclear. Here, we explored the potential role of KDM6A in regulating the ant...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6cd71a3f-daaa-5f04-a198-da44c0bb17ce
DOI: 10.21203/rs.3.rs-114298/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Significance of KDM6A Mutation in Bladder Cancer Immune EscapeDOI 10.21203/rs.3.rs-114298/v1Read

Significance of KDM6A Mutation in Bladder Cancer Immune EscapeSemantic proximity Read

Significance of KDM6A mutation in bladder cancer immune escape.Semantic proximity Read

Development of an m6A subtype classifier to guide precision therapy for patients with bladder cancerSemantic proximity Read

Kdm6a Deficiency Activates Inflammatory Pathways, Promotes M2 Macrophage Polarization, and Causes Bladder Cancer in Cooperation with p53 DysfunctionSemantic proximity Read

CDK6 as a Biomarker for Immunotherapy, Drug Sensitivity, and Prognosis in Bladder Cancer: Bioinformatics and Immunohistochemical Analysis.Semantic proximity Read

A Pan-Cancer Analysis Revealing the Dual Roles of Lysine (K)-Specific Demethylase 6B in Tumorigenesis and ImmunitySemantic proximity Read

EP300 mutation is associated with tumor mutation burden and promotes antitumor immunity in bladder cancer patients.Semantic proximity Read

Concurrent alterations in TERT, KDM6A, and the BRCA pathway in bladder cancer.Semantic proximity Read

Identification and Validation of N6-methyladenosine-related Biomarkers for Bladder Cancer: Implications for ImmunotherapySemantic proximity Read

Lysine N-methyltransferase SETD7 promotes bladder cancer progression and immune escape via STAT3/PD-L1 cascadeSemantic proximity Read

Identification of RB1 Gene as a Immune-Related Prognostic Signature Based on Tumor Mutation Burdens in Bladder CancerSemantic proximity Read

Multi-omics analysis of tumor mutation burden combined with immune infiltrates in bladder urothelial carcinoma.Semantic proximity Read