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Establishing Minimal Conditions Sufficient for the Development of Titan-like Cells in Cryptococcus neoformans/gattii Species Complex

5 Jul 2022

Abstract excerpt

Opportunistic pathogens of the anamorphic genus Cryptococcus are unique considering their virulence factors that in the context of pathogenesis allowed them to achieve evolutionary success. Morphological transformation into giant (Titan) cells is one of the factors contributing to cryptococcosis. Recently established in vitro protocols demonstrate that 5 or 10% fetal bovine serum (FBS) combined with 5% CO2, 37...

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PMID: 35890013
DOI: 10.3390/pathogens11070768

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Related research

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Research trail→

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Establishing Minimal Conditions Sufficient for the Development of Titan-like Cells in Cryptococcus neoformans/gattii Species ComplexPMID 35890013Read ↗

Titan cells formation in Cryptococcus neoformans is finely tuned by environmental conditions and modulated by positive and negative genetic regulators.Semantic proximity Read ↗

Cryptococcus neoformans can form titan-like cells in vitro in response to multiple signals.Semantic proximity Read ↗

Titan cells formation in <i>Cryptococcus neoformans</i> is finely tuned by environmental conditions and modulated by positive and negative genetic regulatorsSemantic proximity Read ↗

Titan cell formation is unique to Cryptococcus species complexSemantic proximity Read ↗

A Glycolysis–Calcineurin Regulatory Axis Orchestrates Titan Cell Formation in <i>Cryptococcus neoformans</i>Semantic proximity Read ↗

The <i>Cryptococcus neoformans</i> Titan cell is an inducible and regulated morphotype underlying pathogenesisSemantic proximity Read ↗

Titan cells in Cryptococcus neoformans: cells with a giant impactSemantic proximity Read ↗

Host environmental conditions induce small fungal cell size and alter population heterogeneity in <i>Cryptococcus neoformans</i>Semantic proximity Read ↗

The Cryptococcus neoformans Titan cell is an inducible and regulated morphotype underlying pathogenesisSemantic proximity Read ↗

The Cryptococcus neoformans Titan Cell: From In Vivo Phenomenon to In Vitro ModelSemantic proximity Read ↗

An <i>in vitro</i> method for inducing titan cells reveals novel features of yeast-to-titan switching in the human fungal pathogen <i>Cryptococcus gattii</i>Semantic proximity Read ↗

The <i>Cryptococcus neoformans</i> titanide is a pathogenic morphotype that arises from typical yeast cells in response to host-relevant conditionsSemantic proximity Read ↗

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