Article

NMDA Receptor Potentiation and Severe Acute Respiratory Syndrome Treatment

2022-03-30

Abstract excerpt

An experimental compound (CNS004), reported to have various biological activities including antiviral, antimalarial, antiprotozoal and immunomodulatory effects, has been identified to potentiate NMDA subtype of glutamate receptors that are expressed in human lungs and central nervous system. We hypothesize that potentiating NMDA receptors will increase calcium ion influx and promote downstream signaling mechanisms...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e90a9861-07b1-513f-a218-f0bde22eef40
DOI: 10.22541/au.164864550.08969022/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 11 closest

NMDA Receptor Potentiation and Severe Acute Respiratory Syndrome TreatmentDOI 10.22541/au.164864550.08969022/v1Read

NMDA receptor modulation and severe acute respiratory syndrome treatmentSemantic proximity Read

Antiviral activity of the non-steroidal anti-inflammatory drug indomethacin against Respiratory Syncytial VirusSemantic proximity Read

Niclosamide potentiates TMEM16A and induces vasoconstrictionSemantic proximity Read

GABA administration limits viral replication and pneumonitis in a mouse model of COVID-19Semantic proximity Read

Inflammatory mediators mediate airway smooth muscle contraction through a G protein-coupled receptor-transmembrane protein 16A-voltage-dependent Ca2+ channel axis and contribute to bronchial hyperresponsiveness in asthma.Semantic proximity Read

The DREAM protein negatively regulates the NMDA receptor through interaction with the NR1 subunit.Semantic proximity Read

A Study on the Effect of Traditional Chinese medicine Chaihu-guizhi Decoction Reducing the Susceptibility and Severity of Influenza in Depressed MiceSemantic proximity Read

Proposed molecular and cellular mechanism for aminoglycoside ototoxicity.Semantic proximity Read

Clinical Application of the Muscle-Relaxant Effects of Magnesium in Anaesthesia: Data from Randomized Trials and Meta-AnalysisSemantic proximity Read

Mechanism of partial agonist action at the NR1 subunit of NMDA receptors.Semantic proximity Read

Supralinear potentiation of NR1/NR3A excitatory glycine receptors by Zn2+ and NR1 antagonist.Semantic proximity Read