Article

RUNX1 is regulated by androgen receptor to promote cancer stem markers and chemotherapy resistance in triple negative breast cancer

2022-11-12

Abstract excerpt

<h4>ABSTRACT</h4> Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype for which no effective targeted therapies are available. Growing evidence suggests that chemotherapy-resistant cancer cells with stem-like properties (CSC) may repopulate the tumor. Androgen receptor (AR) is expressed in up to 50% of TNBC, and AR inhibition decreases CSC and tumor initiation. Runt-related transcription f...

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Literature Corpus work: e9065765-3a48-5262-a107-ddcedf200e38
DOI: 10.1101/2022.11.12.516193

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