Article

DC targeted therapy breaks immune tolerance against neoantigens in refractory lung adenocarcinoma

2023-04-03

Abstract excerpt

<title>Abstract</title> <p>The efficacy of immune checkpoint blockade (ICB) in NSCLC depends on the tumor mutational burden (TMB). However, a fraction of patients with high TMB and predicted immunogenic neoantigens (neoAgs) do not respond. Here we show that in a model of highly mutated NSCLC, cross-presenting cDC1s are required to induce broad effector CD8+ T cell responses to both strong and weak endogenous neoA...

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Literature Corpus work: 0da5ac7f-db55-565e-bf02-d3c3878a6fa7
DOI: 10.21203/rs.3.rs-2752957/v1

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