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Article

Autism-associated variants of neuroligin 4X impair synaptogenic activity by various molecular mechanisms.

Molecular autism - 1 Sept 2020

Yumoto Takafumi, Kimura Misaki, Nagatomo Ryota, Sato Tsukika, Utsunomiya Shun, Aoki Natsue, Kitaura Motoji, Takahashi Koji, Takemoto Hiroshi, Watanabe Hirotaka, Okano Hideyuki, Yoshida Fumiaki, Nao Yosuke, Tomita Taisuke

Abstract excerpt

BACKGROUND: Several genetic alterations, including point mutations and copy number variations in NLGN genes, have been associated with psychiatric disorders, such as autism spectrum disorder (ASD) and X-linked mental retardation (XLMR). NLGN genes encode neuroligin (NL) proteins, which are adhesion molecules that are important for proper synaptic formation and maturation. Previously, we and others found that the...

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Identifiers

PMID: 32873342
DOI: 10.1186/s13229-020-00373-y
PMCID: PMC7465329

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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